SINGAPORE, June 16 (Bernama-GLOBE NEWSWIRE) — Tessa Therapeutics Ltd. (Tessa), a clinical-stage cell therapy company developing next-generation cancer treatments for hematological malignancies and solid tumors, today announced promising safety and efficacy data from a study of its off-the-shelf CD30.CAR EBVST therapy (TT11X) in patients with relapsed or refractory (R/R) Hodgkin lymphoma. The results were presented by Tessa collaborators at the Baylor College of Medicine in an oral podium presentation at the 17th International Conference on Malignant Lymphoma (ICML) taking place at Lugano, Switzerland. TT11X, Tessa’s allogeneic “off-the-shelf” cell therapy, is based on Tessa’s proprietary CD30.CAR-modified Epstein-Barr virus-specific T-cell (EBVST) platform.
The podium presentation (#47), titled, “Off-the-shelf CD30.CAR EBV-specific T cells provide a safe and effective therapy for HL,” reported data from 18 heavily pre-treated patients with R/R Hodgkin lymphoma who were administered TT11X across four dosing levels (40 × 10⁶ CD30.CAR EBVSTs, 100 × 10⁶ CD30.CAR EBVSTs, 400 × 10⁶ CD30.CAR EBVSTs, and 800 × 10⁶ CD30.CAR EBVSTs). An overall response rate of 78% (14/18 patients) was observed across all four dose levels, including seven complete responses and seven partial responses, with higher doses producing improved clinical responses. Additionally, TT11X was demonstrated to be well tolerated with no dose-limiting toxicities observed, including no evidence of graft-versus-host disease (GVHD) or immune effector cell-associated neurotoxicity syndrome (ICANS). Six episodes of possible cytokine release syndrome were all grade one (mildest of four grades).