Oral poster highlights data from 14 heavily pre-treated patients enrolled in pilot stage of multicenter, open-label, single arm CHARIOT study to evaluate safety and efficacy of TT11
TT11 demonstrated compelling anti-tumor activity with complete disappearance of tumor observed in 8 of 14 patients
Therapy well tolerated with no instances of neurotoxicity or Grade 3 CRS
SINGAPORE, Dec 14 (Bernama-GLOBE NEWSWIRE) — Tessa Therapeutics Ltd. (Tessa), a clinical-stage cell therapy company developing next-generation cancer treatments for hematological malignancies and solid tumors, today announced clinical data from the pilot stage of the ongoing Phase 2 CHARIOT trial (NCT04268706) of TT11, the Company’s autologous CD30 chimeric antigen receptor T-cell (CAR-T) therapy. The results demonstrated a favorable safety profile and promising efficacy in relapsed or refractory CD30-positive classical Hodgkin lymphoma (cHL) patients, with a complete response (CR) rate of 57.1 percent and an overall response rate (ORR) of 71.4 percent. The data was presented in an oral poster presentation at the 63rd Annual Meeting of the American Society of Hematology (ASH) and follows a poster presented on December 11 reporting favorable safety and efficacy data in a Phase 1 trial of Tessa’s “off-the-shelf” CD30-CAR EBVST cell therapy in relapsed or refractory CD30-positive lymphomas.