Development of novel Camsirubicin analog expands Monopar’s therapeutic pipeline
WILMETTE, Ill., June 4 (Bernama-GLOBE NEWSWIRE) — Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biopharmaceutical company primarily focused on developing proprietary therapeutics designed to extend life or improve the quality of life for cancer patients, today announced it has entered into a collaboration agreement with the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) to evaluate the activity of MNPR-202 and related analogs in multiple types of cancer. MNPR-202 was designed to retain the same potentially non-cardiotoxic backbone as camsirubicin but is modified at other positions which may enable it to work in certain cancers that are resistant to camsirubicin and doxorubicin. Monopar recently announced a composition of matter U.S. patent (US10,450,340) covering MNPR-202 and related analogs. While we expect camsirubicin to enter a dose escalation run-in clinical trial in advanced soft tissue sarcoma in the second half of this year, CSI Singapore will explore how the immune system recognizes cancer cells treated with MNPR-202 and related analogs in order to guide the rational design of immunotherapy-chemotherapy combinations for the treatment of cancer.
http://mrem.bernama.com/viewsm.php?idm=40202